Assist. Prof. Dr. Celine FABRET | Biology | Best Researcher Award

Lecturer at Paris-Saclay University, France

Dr. Céline Fabret is a Research Associate Professor at Paris-Saclay University, working at the Institut de Biologie Intégrative de la Cellule (I2BC). She holds a Ph.D. in Molecular Biology and Genetics from Université Aix-Marseille II and has extensive postdoctoral experience in both France and the United States. Her research focuses on translation termination, ribosome rescue mechanisms, prion biology, and gene regulation in bacteria and yeast. With a strong background in genetics and RNA biology, she has contributed to several international genome projects and has published in leading journals. Dr. Fabret is also an experienced educator and mentor, actively involved in training students and participating in academic governance.

Publication Profile 

Scopus

Educational Background 🎓

• Ph.D. in Molecular Biology and Genetics, Université Aix-Marseille II, France (1996)

  • Doctoral research at CNRS Marseille, within the European-Japanese Bacillus subtilis genome project

• Master’s in Molecular Biology, Université Aix-Marseille II, France

Professional Experience 💼

• 2025–Present: Research Associate Professor, Paris-Saclay University, I2BC

• 2011–Present: Faculty member, Paris-Saclay University (teaching microbiology, genetics, molecular biology, genomics)

• 2001–2011: Lecturer, Sorbonne University (Pierre et Marie Curie Campus)

• 1999–2001: Researcher in P. Noirot’s lab at INRA, Jouy-en-Josas – Genetic tools development and essential gene characterization

• 1998–1999: Researcher in L. Jannière’s lab at INRA – High-frequency in vivo mutagenesis system in E. coli

• 1996–1998: Postdoctoral Fellow, J.A. Hoch’s Lab, The Scripps Research Institute (La Jolla, USA) – Sporulation and two-component systems in Bacillus subtilis

• 1991–1996: Doctoral researcher, CNRS Marseille – DNA sequencing and transcriptional analysis in B. subtilis

Research Interests 🔬

Dr. Fabret’s research bridges bacterial and eukaryotic translation, gene regulation, and RNA biology. Her focus includes:

• Translation termination mechanisms in yeast and bacteria

• Prion biology and its effect on stop codon recognition ([PSI+] phenotype)

• Ribosome rescue and RNA quality control systems (RQC2, trans-translation)

• Antibiotic response and translational reprogramming in Gram-negative bacteria

• Functional genomics and essential gene analysis in Bacillus subtilis

• Post-transcriptional modifications and their role in translational fidelity

She has supervised 2 PhD theses, 3 Master 2 (M2), and 16 Master 1 (M1) students, contributing to the training of the next generation of molecular biologists.

Awards and Honors🏆✨

• Lead participant in multiple European research consortia on genome projects and enzyme engineering

• Co-author of high-impact publications in Nature Cell Biology, Structure, Nucleic Acids Research, Molecular Microbiology

• Elected member of the Consultative Commission of Biology Specialists and the Biology Department Council, Paris-Saclay University

• Recognized for interdisciplinary collaboration with pharmaceutical companies (e.g., Aventis) and international institutions

Conclusion🌟

Dr. Céline Fabret has made sustained and meaningful contributions to molecular microbiology, translation biology, and bacterial physiology. Through a unique combination of genetic, biochemical, and functional genomics approaches, she has deepened our understanding of translation mechanisms and gene regulation across domains of life. As a researcher, educator, and mentor, she remains committed to advancing science and supporting young scientists in their careers.

Publications 📚

1. 🧬 Fabret C, Giudice E, Chat S, Gillet R, Namy O (2025)
   RQC2 is a major player in peptide release from stalled ribosomes
   Structure, 31: S0969-2126(25)00105-4.

   ---

2. 🦠 Fruchard L, Babosan A, Carvalho A, Lang M, Li B, Duchateau M, Giai Gianetto Q, Matondo M, Bonhomme F, Hatin I, Arbes H, Fabret C, et al. (2025)
   Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming
   (Accepted, journal not specified).

   ---

3. 🧪 Fabret C, Namy O (2021)
   Translation efficiency of E. coli ribosomes with covalently linked subunits
   Nucleic Acids Research, 49(9): 5308–5318.

   ---

4. 🔬 Malagnac*, Fabret* et al. (2013)
   A gene regulated by a -1 frameshift in Podospora anserina
   PLoS One, 8(9): e73772. (co-first authors)

   ---

5. 🔎 Cosnier B, Kwapisz M, Hatin I, Namy O, Fabret C (2011)
   Translational readthrough of S. cerevisiae genes IMP3 and PDE2
   PLoS One, 6(4): e19500.

   ---

6. 🧫 Desmolaize B, Fabret C, Graille M, van Tilbeurgh H, Brochier-Armanet C, Namy O (2011)
   23S rRNA modifications in Bacillus subtilis
   Nucleic Acids Research, 39(21): 9368–9375.

   ---

7. 🧬 Fabret C, Malagnac F, Namy O (2011)
   tRNA-CAU modification enzyme and AUA codon recognition in Bacillus subtilis
   Molecular Microbiology, 80(4): 1062–1074.

   ---

8. 💡 Blanchet S, Cornu D, Hatin I, Grosjean H, Bertin P, Namy O, Fabret C (2015)
   eRF1 interactions with stop codons and the ribosome
   Nucleic Acids Research, 43(6): 3298–3308.

   ---

9. 🧠 Kabani M, Melki R, Fabret C (2011)
   Prion formation and the eRF3 protein in yeast
   Molecular Microbiology, 81(3): 640–658.

   ---

10. 🔬 Tork S, Hatin I, Rousset JP, Fabret C (2004)
    5′ and 3′ context effects on stop codon recognition
    Nucleic Acids Research, 32(2): 415–421.

    ---