Full-time teacher at Hubei University of Education, China
Dr. Didi Chen is a materials chemist and fluorescence imaging researcher affiliated with the School of Chemistry and Life Sciences, Hubei University of Education. His research primarily focuses on the design and development of fluorescent bioprobes based on Aggregation-Induced Emission (AIE) for biomedical applications such as tumor detection, intraoperative imaging, and biomarker quantification. With multiple publications in high-impact journals and a leading role in national-level research projects, Dr. Chen is contributing to the advancement of bioimaging technologies for real-time diagnostics and cancer surgery guidance.
Publication Profile
Scopus
Educational Background 🎓
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Ph.D. in Materials Science and Engineering
Beijing Institute of Technology
September 2013 – June 2017
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Master’s Degree in Chemistry
School of Chemistry, Central China Normal University
September 2009 – June 2012
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Bachelor’s Degree in Chemistry
College of Chemistry, Central China Normal University
September 2005 – June 2009
Professional Experience 💼
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Faculty Member, School of Chemistry and Life Sciences, Hubei University of Education
Engaged in teaching and research in materials chemistry and bioimaging.
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Principal Investigator, National Natural Science Foundation of China (NSFC) Project for Young Scientists (Project No. 22405079)
2025–2027: Project on real-time navigation of liver cancer surgery using AIE-based fluorescent probes.
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Active contributor to multidisciplinary research projects in molecular design, bio-detection, and fluorescence-guided surgery.
Research Interests 🔬
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Aggregation-Induced Emission (AIE) and its application in:
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Fluorescent probe design
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Bioimaging and surgical guidance
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Tumor microenvironment studies
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Biomolecular sensing (e.g., CO₂, HSA, FIB)
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Intraoperative imaging techniques for early cancer diagnosis
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Interaction studies between stromal and tumor cells using AIEgens
Awards and Honors🏆✨
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Principal Investigator, National Natural Science Foundation of China for Young Scientists (2025–2027)
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Recognition through peer-reviewed publications in top-tier journals such as Biomaterials, Analytica Chimica Acta, Materials Chemistry Frontiers, Sensors and Actuators B, and Aggregate.
Conclusion🌟
Dr. Didi Chen is an emerging leader in the field of fluorescent bio-probe development for cancer diagnostics and intraoperative applications. His work integrates innovative materials chemistry with real-world clinical challenges, contributing significantly to non-invasive imaging and tumor identification. He has demonstrated capability in acquiring competitive research funding, publishing impactful studies, and advancing knowledge at the interface of chemistry, biology, and medicine.
Given his strong academic background, successful grant leadership, and impactful publication record, Dr. Chen is well-positioned for continued contributions to translational biomedical research and qualifies as a strong candidate for research awards and honors in the fields of chemistry and medical diagnostics.
Publications 📚
1️⃣ 🧪 ND-TPE-COOH: Protein-activated fluorescent diagnostic probes for rapid identification and resection of liver tumors
👩🔬 Qu, J., Li, Z., Zhong, H., Mukerabigwi, J.F., Cao, Y.
📘 Sensors and Actuators B: Chemical, 2025
🔬 Focus: Development of a novel fluorescent probe for rapid liver tumor diagnosis and surgical assistance.
2️⃣ 🧬 Fluorescence-guided Surgery for Hepatocellular Carcinoma: From Clinical Practice to Laboratories
👨⚕️ Xiao, T., Chen, D., Peng, L., Zhang, J., Li, M.
📕 Review Article, 2025
📈 Citations: 2
💡 Scope: Bridging clinical application and lab development in fluorescence-guided liver cancer surgery.
3️⃣ 💡 The Fluorescent Bioprobe with Aggregation-Induced Emission Features for Monitoring Carbon Dioxide Generation in Single Living Cells
🔬 Chen, D., Wang, H., Dong, L., Liu, P., Zhang, Y., Shi, J., Feng, X., Zhi, J., Tong, B., Dong, Y.
📘 Biomaterials, 2016, 103: 67–74
🧫 Highlights: Real-time CO₂ tracking and early cancer cell detection using AIE-based probes.
4️⃣ 🧪 Two-Step Separation-Free Quantitative Detection of HSA and FIB in Human Plasma using an AIE Probe
🔬 Chen, D., Dong, L., Jiang, S., Li, W., Shi, J., Feng, X., Zhi, J., Tong, B., Li, M., Zheng, Q., Dong, Y.
📙 Sensors and Actuators B: Chemical, 2018, 255: 854–861
💉 Purpose: Efficient biomarker detection without sample separation steps.
5️⃣ 🔬 CO₂-Sensitive AIEgen for Analyzing Tumor-Stroma Interactions in Heterocellular Systems
🔍 Chen, D., Wang, H., Liu, P., Song, L., Shi, J., Tong, B., Dong, Y.
📗 Analytica Chimica Acta, 2018, 1001: 151–157
🧬 Focus: Understanding tumor microenvironment dynamics.
6️⃣ 🧿 A Novel Turn-on Fluorescent Probe for Intraoperative Diagnosis of Hepatocellular Carcinoma
🧪 Chen, D.#, Mao, H.#, Hong, Y., Tan, Y., Zhang, Y., Li, M., Dong, Y.
📕 Materials Chemistry Frontiers, 2020, 4: 2716–2722
🔎 Innovation: Rapid pathological differentiation during surgery using AIEgen derivatives.
7️⃣ 💡 A Simple “Spraying” Fluorescence-Guided Surgery for Liver Tumor Resection
🔬 Chen, D., Xiao, T., Wang, L., Chen, S., Kam, C., Zeng, G., Peng, L., Zhang, J., Li, M., Dong, Y.
📘 Aggregate, 2024, 5: e550
🧠 Impact: Introducing non-invasive, intraoperative tumor visualization via sprayable AIE probes.