Shanty A.A | Biochemistry | Best Researcher Award

Published on by Innovation Technologist

Dr. Shanty A.A | Biochemistry | Best Researcher Award

Assistant Professor at St. Teresa’s College | India

Dr. Shanty Antony Angamaly is an accomplished Assistant Professor at St. Teresa’s College, Ernakulam, specializing in Inorganic Chemistry, Biochemistry, and Analytical Chemistry. She earned her Ph.D. in Bioinorganic Chemistry under the guidance of Dr. P.V. Mohanan, focusing on heterocyclic Schiff bases and their transition metal complexes as versatile pharmacophores. Her research expertise spans inorganic and bioinorganic chemistry, analytical methods, molecular docking, sensor development, and biological assays. She has extensive experience working with modern analytical instruments including UV-Visible, FT-IR, fluorescence, CD spectrometers, GC-MS, LC-MS, and voltammetric techniques. Dr. Shanty has authored several high-impact publications in international peer-reviewed journals, contributing significantly to the fields of metal complexes, DNA binding studies, enzyme inhibition, fluorescence sensors, and computational chemistry. She has presented her research at multiple national and international conferences and received recognition through awards such as the Young Scientist Award, Best Paper Award, and Young Woman Researcher in Chemistry Award. In addition to research, she is an experienced educator, having guided M.Phil. and postgraduate students, and served as a guest lecturer and external examiner. She actively contributes to professional societies as a reviewer, organizes academic and scientific programs, and mentors students in research and professional development, demonstrating a strong commitment to advancing chemistry education and research.

Profile: Google Scholar

Featured Publications

  • Angamaly, A. A., & Mohanan, P. V. (2021). Synthesis, characterization, DNA binding, antibacterial, antidiabetic, molecular docking and DFT studies of Ni(II), Cu(II) and Zn(II) complexes derived from heterocyclic Schiff base. Inorganic and Nano-Metal Chemistry.

  • Gopalakrishnan, A. K., Angamaly, S. A., & Mohanan, P. V. (2021). An insight into the biological properties of imidazole-based Schiff bases: A review. ChemistrySelect.

  • Gopalakrishnan, A. K., Angamaly, S. A., Pradeep, S. D., Madhusoodhanan, D. T., Manoharan, D. K., & Mohanan, P. V. (2021). A novel imidazole bound Schiff base as highly selective “turn-on” fluorescence sensor for Zn²⁺ and colorimetric kit for Co²⁺. Journal of Fluorescence.

  • Shanty, A. A., Raghu, G., & Mohanan, P. V. (2019). Synthesis, characterization, spectral and theoretical, molecular docking and in vitro studies of copper complexes with HIV RT enzyme. Journal of Molecular Structure, 1197, 154–163.

  • Angamaly, A. A., & Mohanan, P. V. (2018). Heterocyclic Schiff bases as non-toxic antioxidants: Solvent effect, structure activity relationship and mechanism of action. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 192, 181–187.

 

 

Liu Zhemin | Protein Engineering | Best Researcher Award

Published on by Innovation Technologist

Dr. Liu Zhemin | Protein Engineering | Best Researcher Award

Senior Scientist at Nanjing Vazyme Biotechnology Company, China

🔬🎓 Dr. Z. Liu is a distinguished scientist specializing in enzyme engineering and microbial biotechnology. With expertise in protein rational design, directed evolution, and computational modeling, he focuses on developing high-performance enzymes for industrial and medical applications. A prolific researcher and innovator, Dr. Liu integrates cutting-edge techniques like CRISPR-assisted rational design and cooperative substitution methods to advance enzymology. 🌟📈👨‍🔬

Publication Profile : 

Scopus

Educational Background 🎓

Z. Liu has a strong academic foundation in biochemistry and molecular biology, with advanced training in enzyme engineering and microbial biotechnology. His education laid the groundwork for his expertise in protein design, directed evolution, and enzyme applications.

Professional Experience 💼

Z. Liu is a leading researcher and academic in the fields of enzyme engineering and microbial biotechnology. He has contributed extensively to the design and optimization of enzymes for industrial and therapeutic applications, including the development of high-stability enzymes and efficient expression systems in microbial hosts such as Pichia pastoris. His professional work includes the rational design of enzymes using surface charge modifications, directed evolution for improved catalytic properties, and genome editing to enhance enzyme functionality. His research spans collaborations with industry and academia, focusing on practical solutions for enzyme stability, catalytic efficiency, and prebiotic preparation.

Research Interests 🔬

Z. Liu’s research is centered on:

  • Rational Protein Design: Enhancing enzyme stability and activity using computational modeling and experimental methods.
  • Directed Evolution: High-throughput screening and mutagenesis to optimize enzyme performance.
  • Microbial Biotechnology: Developing superior expression systems in microbes like Pichia pastoris for large-scale enzyme production.
  • Enzyme Applications: Innovations in the preparation of prebiotic mannooligosaccharides and other industrial applications.
  • Thermostable Enzymes: Engineering enzymes for high-temperature and low-pH conditions.

Publications 📚

  • Z. Liu, X. Fu, M. Yuan, Q. Liang, C. Zhu, H. Mou, Surface charged amino acid-based strategy for rational engineering of kinetic stability and specific activity of enzymes: Linking experiments with computational modeling. Int. J. Biol. Macromol. 182, 228–236 (2021).
  • M. Wu, L. Cao, W. Tang, Z. Liu*, S. Feng, Improving the anti-autolytic ability of alkaline protease from Bacillus alcalophilus by a rationally combined strategy. Enzyme Microb. Technol., 110561 (2024).
  • Z. Liu, L. Cao, X. Fu, Q. Liang, H. Sun, H. Mou, *A multi-functional genetic manipulation system and its use in high-level expression of a β-mannanase mutant with high specific activity in Pichia pastoris. Microb. Biotechnol. 14, 1525–1538 (2021).
  • W. Zhang#, Z. Liu#, S. Zhou, H. Mou, R. Zhang, Cloning and expression of a β-mannanase gene from Bacillus sp. MK-2 and its directed evolution by random mutagenesis. Enzyme Microb. Technol. 124, 70–78 (2019).
  • Z. Liu, C. Ning, M. Yuan, X. Fu, S. Yang, X. Wei, M. Xiao, H. Mou, C. Zhu, High-efficiency expression of a superior β-mannanase engineered by cooperative substitution method in Pichia pastoris and its application in preparation of prebiotic mannooligosaccharides. Bioresour. Technol. 311, 123482 (2020).
  • Z. Liu, L. Cao, X. Fu, Q. Liang, H. Sun, H. Mou, *A multi-functional genetic manipulation system and its use in high-level expression of a β-mannanase mutant with high specific activity in Pichia pastoris. Microb. Biotechnol. 14, 1525–1538 (2021).
  • Q. Liang, L. Cao, C. Zhu, Q. Kong, H. Sun, F. Zhang, H. Mou, Z. Liu*, *Characterization of recombinant antimicrobial peptide BMGlv2 heterologously expressed in Trichoderma reesei. Int. J. Mol. Sci. 23 (2022). doi:10.3390/ijms231810291.
  • W. Zhang#, Z. Liu#, S. Zhou, H. Mou, R. Zhang, Cloning and expression of a β-mannanase gene from Bacillus sp. MK-2 and its directed evolution by random mutagenesis. Enzyme Microb. Technol. 124, 70–78 (2019).
  • Z. Liu, C. Ning, M. Yuan, X. Fu, S. Yang, X. Wei, M. Xiao, H. Mou, C. Zhu, High-efficiency expression of a superior β-mannanase engineered by cooperative substitution method in Pichia pastoris and its application in preparation of prebiotic mannooligosaccharides. Bioresour. Technol. 311, 123482 (2020).
  • Z. Liu, C. Ning, M. Yuan, S. Yang, X. Wei, M. Xiao, X. Fu, C. Zhu, H. Mou, High-level expression of a thermophilic and acidophilic beta-mannanase from Aspergillus kawachii IFO 4308 with significant potential in mannooligosaccharide preparation. Bioresour. Technol. 295, 122257 (2019).